Human herpesvirus 6: molecular biology and clinical features
نویسندگان
چکیده
منابع مشابه
Human herpesvirus 6: molecular biology and clinical features.
Human herpesvirus 6 (HHV-6) exists as distinct variants HHV-6A and HHV-6B. The complete genomes of HHV-6A and HHV-6B have been sequenced. HHV-6B contains 97 unique genes. CD46 is the cell receptor for HHV-6, explaining its broad tissue tropism but its restricted host-species range. HHV-6 utilizes a number of strategies to down-regulate the host immune response, including molecular mimicry by pr...
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Human herpesvirus 6 (HHV-6) is a betaherpesvirus that is closely related to human cytomegalovirus. It was discovered in 1986, and HHV-6 literature has expanded considerably in the past 10 years. We here present an up-to-date and complete overview of the recent developments concerning HHV-6 biological features, clinical associations, and therapeutic approaches. HHV-6 gene expression regulation a...
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Human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) are members of the Roseolovirus genus within the Betaherpesvirinae subfamily. HHV-6 and HHV-7 primary infection occurs in early childhood and causes short febrile diseases, sometimes associated with cutaneous rash (exanthem subitum). Both HHV-6 and HHV-7 are highly prevalent in the healthy population, establish latency in macrophages a...
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Human herpesvirus 6 (HHV-6) infection was studied in 82 bone marrow transplant (BMT) recipients (72 allogeneic, 10 autologous). All recipients and 30 donors were seropositive for HHV-6 antibody at the time of bone marrow transplantation. Thirty-one recipients (37.8%) had HHV-6 viremia 2-4 weeks after transplantation. The incidence of HHV-6 viremia was significantly higher among allogeneic BMT r...
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Background: Pityriasis rosea (PR) is a common papulosquamousskin disorder that is suspected to have an infectious etiology.We aimed to study the role of human herpesvirus-6 (HHV-6) inthe pathogenesis of PR.Method: We used immunohistochemical (IHC) assays to detectHHV-6 in patients with PR. Fifty-one patients with PR and 35 ageand sex matched healthy control samples were enrolled in thestudy. Th...
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ژورنال
عنوان ژورنال: Journal of Medical Microbiology
سال: 2003
ISSN: 0022-2615,1473-5644
DOI: 10.1099/jmm.0.05074-0